Young man staring out window









According to one study, depression costs the U.S. economy $210 billion annually. It strikes every race, social class, and geographical region. It affects highly accomplished professionals, children, and the elderly. Its human toll can be seen in work days lost, in its high co-occurrence with substance use disorders, and in the fact that suicide is now the 10th leading cause of death for Americans. Depression is the most common serious mental illness, and every advance in our understanding of its causes, treatments, and societal impact is deserving of attention.

Brain-Altering Science and the Search for a New Normal

In 2006, Liss Murphy was in thrall to what she calls a “sepsis of the soul” — an intractable and debilitating depression. No conventional treatments had helped. So when she heard that doctors at Massachusetts General Hospital, in Boston, had developed an experimental cure for severe depression that involved permanently implanting electrodes in the brain, she didn’t Read more

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